Ras陷入另一段关系：Ral的交换因子
Ras caught in another affair: the exchange factors for Ral.
作者信息
Wolthuis R M, Bos J L
机构信息
Laboratory for Physiological Chemistry, Center for Biomedical Genetics,Stratenum, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands.
出版信息
Curr Opin Genet Dev. 1999 Feb;9(1):112-7. doi: 10.1016/s0959-437x(99)80016-1.
Abstract
The Ral guanine nucleotide exchange factors are direct targets of Ras, providing a mechanism for Ral activation by extracellular signals. In addition, Ral can be activated by a Ras-independent pathway. Ral guanine nucleotide exchange factors contribute to cellular transformation induced by oncogenic Ras through an Erk-independent mechanism which may involve activation of transcription.
摘要
Ral鸟嘌呤核苷酸交换因子是Ras的直接靶点，为细胞外信号激活Ral提供了一种机制。此外，Ral可通过一条不依赖Ras的途径被激活。Ral鸟嘌呤核苷酸交换因子通过一种不依赖Erk的机制（可能涉及转录激活）促进致癌Ras诱导的细胞转化。
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