Sharpless N E, DePinho R A
Dana Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA.
Curr Opin Genet Dev. 1999 Feb;9(1):22-30. doi: 10.1016/s0959-437x(99)80004-5.
The INK4A/ARF locus on chromosome 9 is one of the sites mutated most frequently in human cancer. Two genes comprising overlapping reading frames encoding p16(INK4a) and p19(ARF) have been discovered at this locus and, remarkably, both play an important role in regulating cell growth, survival and senescence.
位于9号染色体上的INK4A/ARF基因座是人类癌症中突变最为频繁的位点之一。在该基因座上已发现两个包含重叠阅读框的基因，它们分别编码p16(INK4a)和p19(ARF)，而且值得注意的是，二者在调节细胞生长、存活及衰老过程中均发挥着重要作用。
