Temple S, Alvarez-Buylla A
Department of Pharmacology and Neuroscience A-60 The Albany Medical College Albany New York 12208 USA.
Curr Opin Neurobiol. 1999 Feb;9(1):135-41. doi: 10.1016/s0959-4388(99)80017-8.
Over the past year, evidence has accrued that adult CNS stem cells are a widespread progenitor cell type. These cells may normally replace neurons and/or glia in the adult brain and spinal cord. Advances have been made in understanding the signals that regulate stem cell proliferation and differentiation. A deeper understanding of the structure of germinal zones has helped us move towards identifying stem cells in vivo. Recent studies suggest that the fate of stem cell progeny in vivo may be linked to the complexity of the animal's environment.
在过去的一年里，越来越多的证据表明成体中枢神经系统干细胞是一种广泛存在的祖细胞类型。这些细胞可能在正常情况下替代成体脑和脊髓中的神经元和/或神经胶质细胞。在理解调节干细胞增殖和分化的信号方面已经取得了进展。对生发区结构的更深入了解有助于我们在体内识别干细胞。最近的研究表明，体内干细胞后代的命运可能与动物环境的复杂性有关。
