通过空间聚焦文库获得高亲和力的、靶向SH2的配体。 - Suppr

Acquisition of high-affinity, SH2-targeted ligands via a spatially focused library.

作者信息

Lee T R, Lawrence D S

机构信息

Department of Biochemistry, The Albert Einstein College of Medicine of Yeshiva University, 1300 Morris Park Avenue, Bronx, New York 10461-1602, USA.

出版信息

J Med Chem. 1999 Mar 11;42(5):784-7. doi: 10.1021/jm980663f.

DOI:10.1021/jm980663f

PMID:10072676

Abstract

摘要

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Acquisition of high-affinity, SH2-targeted ligands via a spatially focused library.通过空间聚焦文库获得高亲和力的、靶向SH2的配体。

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Macrocyclization in the design of non-phosphorus-containing Grb2 SH2 domain-binding ligands.不含磷的Grb2 SH2结构域结合配体设计中的大环化

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Macrocyclization in the design of Grb2 SH2 domain-binding ligands exhibiting high potency in whole-cell systems.在全细胞系统中具有高效能的Grb2 SH2结构域结合配体设计中的大环化作用

J Med Chem. 2003 Jan 16;46(2):244-54. doi: 10.1021/jm0203635.

Investigation of the binding determinants of phosphopeptides targeted to the SRC homology 2 domain of the signal transducer and activator of transcription 3. Development of a high-affinity peptide inhibitor.针对信号转导与转录激活因子3的SRC同源2结构域的磷酸肽结合决定簇的研究。一种高亲和力肽抑制剂的开发。

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SH2-directed ligands of the Lck tyrosine kinase.

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Angiotensin II pseudopeptides containing 1,3,5-trisubstituted benzene scaffolds with high AT2 receptor affinity.含有具有高AT2受体亲和力的1,3,5-三取代苯支架的血管紧张素II假肽。

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Structural and conformational requirements for high-affinity binding to the SH2 domain of Grb2(1).与Grb2(1)的SH2结构域高亲和力结合的结构和构象要求。

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Surface plasmon resonance thermodynamic and kinetic analysis as a strategic tool in drug design. Distinct ways for phosphopeptides to plug into Src- and Grb2 SH2 domains.表面等离子体共振热力学和动力学分析作为药物设计中的一种战略工具。磷酸肽插入Src和Grb2 SH2结构域的不同方式。

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Acquisition of high-affinity, SH2-targeted ligands via a spatially focused library.

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