通过空间聚焦文库获得高亲和力的、靶向SH2的配体。 - Suppr

Acquisition of high-affinity, SH2-targeted ligands via a spatially focused library.

作者信息

Lee T R, Lawrence D S

机构信息

Department of Biochemistry, The Albert Einstein College of Medicine of Yeshiva University, 1300 Morris Park Avenue, Bronx, New York 10461-1602, USA.

出版信息

J Med Chem. 1999 Mar 11;42(5):784-7. doi: 10.1021/jm980663f.

DOI:10.1021/jm980663f

PMID:10072676

Abstract

摘要

相似文献

Acquisition of high-affinity, SH2-targeted ligands via a spatially focused library.通过空间聚焦文库获得高亲和力的、靶向SH2的配体。

J Med Chem. 1999 Mar 11;42(5):784-7. doi: 10.1021/jm980663f.

Design of tetrapeptide ligands as inhibitors of the Src SH2 domain.作为Src SH2结构域抑制剂的四肽配体设计

Bioorg Med Chem. 2004 Feb 15;12(4):779-87. doi: 10.1016/j.bmc.2003.10.060.

Conformationally constrained peptide analogues of pTyr-Glu-Glu-Ile as inhibitors of the Src SH2 domain binding.作为Src SH2结构域结合抑制剂的pTyr-Glu-Glu-Ile的构象受限肽类似物。

J Med Chem. 2004 Jun 3;47(12):3131-41. doi: 10.1021/jm040008+.

Macrocyclization in the design of non-phosphorus-containing Grb2 SH2 domain-binding ligands.不含磷的Grb2 SH2结构域结合配体设计中的大环化

J Med Chem. 2004 Apr 8;47(8):2166-9. doi: 10.1021/jm030510e.

Macrocyclization in the design of Grb2 SH2 domain-binding ligands exhibiting high potency in whole-cell systems.在全细胞系统中具有高效能的Grb2 SH2结构域结合配体设计中的大环化作用

J Med Chem. 2003 Jan 16;46(2):244-54. doi: 10.1021/jm0203635.

Investigation of the binding determinants of phosphopeptides targeted to the SRC homology 2 domain of the signal transducer and activator of transcription 3. Development of a high-affinity peptide inhibitor.针对信号转导与转录激活因子3的SRC同源2结构域的磷酸肽结合决定簇的研究。一种高亲和力肽抑制剂的开发。

J Med Chem. 2005 Oct 20;48(21):6661-70. doi: 10.1021/jm050513m.

SH2-directed ligands of the Lck tyrosine kinase.

J Med Chem. 2000 Mar 23;43(6):1173-9. doi: 10.1021/jm990462r.

Angiotensin II pseudopeptides containing 1,3,5-trisubstituted benzene scaffolds with high AT2 receptor affinity.含有具有高AT2受体亲和力的1,3,5-三取代苯支架的血管紧张素II假肽。

J Med Chem. 2005 Oct 20;48(21):6620-31. doi: 10.1021/jm050280z.

Structural and conformational requirements for high-affinity binding to the SH2 domain of Grb2(1).与Grb2(1)的SH2结构域高亲和力结合的结构和构象要求。

J Med Chem. 1999 Mar 25;42(6):971-80. doi: 10.1021/jm9811007.

Surface plasmon resonance thermodynamic and kinetic analysis as a strategic tool in drug design. Distinct ways for phosphopeptides to plug into Src- and Grb2 SH2 domains.表面等离子体共振热力学和动力学分析作为药物设计中的一种战略工具。磷酸肽插入Src和Grb2 SH2结构域的不同方式。

J Med Chem. 2005 Feb 10;48(3):753-63. doi: 10.1021/jm049359e.

引用本文的文献

SRC kinase regulation in progressively invasive cancer.Src 激酶在不断侵袭性癌症中的调控。

PLoS One. 2012;7(11):e48867. doi: 10.1371/journal.pone.0048867. Epub 2012 Nov 7.

Synthesis and screening of a haloacetamidine containing library to identify PAD4 selective inhibitors.合成并筛选含卤乙酰胺基的文库，以鉴定 PAD4 选择性抑制剂。

ACS Chem Biol. 2012 Jan 20;7(1):160-5. doi: 10.1021/cb200258q. Epub 2011 Oct 21.

Light-mediated liberation of enzymatic activity: "small molecule" caged protein equivalents.光介导的酶活性释放：“小分子”笼形蛋白类似物。

J Am Chem Soc. 2008 Aug 13;130(32):10474-5. doi: 10.1021/ja803395d. Epub 2008 Jul 19.

The specificity of the protein kinase C alpha, betaII and gamma isoforms as assessed by an unnatural alcohol-appended peptide library.通过一个连接非天然醇的肽文库评估蛋白激酶Cα、βII和γ亚型的特异性。

Biochem J. 2000 Aug 1;349 Pt 3(Pt 3):709-15. doi: 10.1042/bj3490709.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Acquisition of high-affinity, SH2-targeted ligands via a spatially focused library.

作者信息

机构信息

出版信息

相似文献

引用本文的文献

文献检索

文件翻译

深度研究

Suppr 超能文献

相似文献

引用本文的文献