[慢性肺心病患者运动试验时血浆内皮源性舒张因子和内皮素-1的变化]
[Changes of plasma endothelium-derived relaxing factor and endothelin-1 in patients with chronic cor pulmonale at exercise test].
作者信息
Guo S, Dai H, Wang C
机构信息
Beijing Red Cross Chaoyang Hospital, Beijing.
出版信息
Zhonghua Jie He He Hu Xi Za Zhi. 1997 Feb;20(1):20-1.
OBJECTIVE
The authers investigated the levels of plasma EDRF-nitric oxide (NO) and ET-1 in 10 cases of cor pulmonale at exercise.
METHODS
Using the technologies of cardiac catheter, radioimmunization and biochemical analysis.
RESULTS
The level of plasma NO was lower in group A (mean pulmonary artery pressure (mPAP) < 2.67 kPa) than in group B (mPAP > or = 2.67 kPa) at rest; the content of plasma NO increased more markedly in group A than in group B during exercise; there was no change in the content of ET-1 in both groups; mPAP strongly correlated with plasma NO or ET-1 in both groups.
CONCLUSIONS
The patients with cor pulmonale at early stage may be in a state of compensated release of NO, but its release reserve has been reduced.
目的
作者研究了10例肺心病患者运动时血浆内皮舒张因子 - 一氧化氮（NO）和内皮素 - 1（ET - 1）的水平。
方法
采用心导管、放射免疫和生化分析技术。
结果
静息时，A组（平均肺动脉压（mPAP）<2.67 kPa）血浆NO水平低于B组（mPAP≥2.67 kPa）；运动期间，A组血浆NO含量增加比B组更显著；两组ET - 1含量均无变化；两组中mPAP与血浆NO或ET - 1均呈强相关。
结论
早期肺心病患者可能处于NO代偿性释放状态，但其释放储备已降低。
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