Wang Q, Zhang X, Kang J
Institute of Respiratory Disease, China Medical University, Shenyang.
Zhonghua Jie He He Hu Xi Za Zhi. 1997 Aug;20(4):222-4.
To study the effect and mechanism of 8-methoxypsoralen (8-MOP) relaxing human pulmonary arteries.
Observe effects of 8-MOP on the isolated human pulmonary artery rings(PAR) obtained from 11 patients undergoing lobectomy for lung carcinoma.
(1)8-MOP(2 x 10(-5) mol/L) caused significant relaxation of PAR precontracted with noradreline (NA) by 88% (P < 0.001) and this effect of 8-MOP was independent on the endothelium of the pulmonary arteries. (2) The contraction of PAR induced by NA was significantly inhibited by 8-MOP(2 x 10(-5) mol/L) and the percentage of inhibition was 89% (P < 0.001). (3) The contractile dose-response curve of PAR induced by NA was shifted to the right and maximal contractile response was inhibited about 55% by 8-MOP, PD'2 = 4.79.
8-MOP can significantly relax pulmonary arteries and 8-MOP may become an effective vasodilator for pulmonary hypertension.
研究8-甲氧基补骨脂素（8-MOP）舒张人肺动脉的作用及机制。
观察8-MOP对11例因肺癌行肺叶切除术患者的离体人肺动脉环（PAR）的作用。
（1）8-MOP（2×10⁻⁵mol/L）使由去甲肾上腺素（NA）预收缩的PAR显著舒张88%（P<0.001），且8-MOP的这种作用不依赖于肺动脉内皮。（2）8-MOP（2×10⁻⁵mol/L）显著抑制NA诱导的PAR收缩，抑制率为89%（P<0.001）。（3）8-MOP使NA诱导的PAR收缩剂量-反应曲线右移，最大收缩反应被抑制约55%，PD'2 = 4.79。
8-MOP能显著舒张肺动脉，8-MOP可能成为治疗肺动脉高压的有效血管扩张剂。
