15例毛母质癌的临床病理研究

[Clinicopathological study on 15 cases of pilomatrix carcinoma].

作者信息

Li X, Jiang H, Li A

机构信息

Central Hospital of Shengli Petroleum Administration Bureau, Shangdong.

出版信息

Zhonghua Bing Li Xue Za Zhi. 1997 Apr;26(2):100-2.

PMID:10072881

Abstract

OBJECTIVE

To analyse the pathomorphology and the clinical biological behavior of pilomatrix carcinoma as well as to clarify the main points of diagnosis and differential diagnosis.

METHODS

A review of the clinicopathological, histochemical and immunohistochemical features of 15 pilomatrix carcinomas a well as their clinical data was made.

RESULTS

Of the 15 cases, 6 were male and 9 female, aged 11 to 83 (mean age 46 years). The tumor diameter varied from 1.2 cm to 8.0 cm (mean 3.5 cm). Histologically, pilomatrix carcinomas are characterized by sheets and islands of proliferating atypical baseloid cells with an infiltrating border. Transition to squamous, clear and ghost cell are often observed. The trichohyalin granules and tricholin-like acidophilic bodies are seen in tumor cells. Follow-up on 13 cases revealed local recurrence in 7 cases with multiple recurrence in 2 cases. One died of liver metastasis and one died of extensive local spread of the tumor.

CONCLUSION

Pilomatrix carcinoma is a malignant tumor which usually recurs. Better curative results are obtained by wide excision.

摘要

目的

分析毛母质癌的病理形态学及临床生物学行为，明确其诊断及鉴别诊断要点。

方法

回顾性分析15例毛母质癌的临床病理、组织化学及免疫组化特征以及临床资料。

结果

15例中，男性6例，女性9例，年龄11至83岁（平均年龄46岁）。肿瘤直径1.2 cm至8.0 cm不等（平均3.5 cm）。组织学上，毛母质癌表现为增生的非典型基底样细胞呈片状及岛状排列，边界浸润性生长。常可见向鳞状细胞、透明细胞及影细胞的转变。肿瘤细胞内可见毛透明蛋白颗粒及类毛透明酸嗜酸性小体。13例随访结果显示，7例局部复发，2例多次复发。1例死于肝转移，1例死于肿瘤广泛局部扩散。