短期和长期处于糖尿病状态的大鼠体内山梨醇的蓄积情况。
Sorbitol accumulation in rats kept on diabetic condition for short and prolonged periods.
作者信息
Ferraz M, Ishii-Iwamoto E L, Batista M R, Brunaldi K, Bazotte R B
机构信息
Universidade Paranaense, Umuarama, PR, Brazil.
出版信息
Zhongguo Yao Li Xue Bao. 1997 Jul;18(4):309-11.
AIM
To study the influence of the course of diabetes, aging, and glycemia on the sorbitol accumulation in diabetic rats.
METHODS
Streptozocin (Str) diabetic rats were obtained by Str i.v. (35 mg.kg-1). Glycemia and sorbitol levels from sciatic nerve and lens were measured after 1 d, 2, 5, and 8 months of diabetes. Sorbitol concentrations in serum, heart, diaphragm, small intestine, and kidney after 8 months of diabetes were measured.
RESULTS
Diabetic rats after Str injection showed hyperglycemia (> 1.7 g.L-1), hyperphagia, polyuria, polydipsia, and loss of body weight. Sorbitol levels in lens and sciatic nerve increased in normal and diabetic rats; the increase was higher in diabetic rats. No relationship was shown between glycemia and sorbitol levels. An increased sorbitol level after 8 months of diabetes was found in small intestine and kidney.
CONCLUSION
The sorbitol levels increased in lens and sciatic nerve with aging and this process was accelerated by diabetes.
目的
研究糖尿病病程、衰老及血糖水平对糖尿病大鼠山梨醇蓄积的影响。
方法
通过静脉注射链脲佐菌素（Str，35mg·kg-1）制备糖尿病大鼠。在糖尿病病程1天、2个月、5个月和8个月后，测定坐骨神经和晶状体中的血糖及山梨醇水平。在糖尿病病程8个月后，测定血清、心脏、膈肌、小肠和肾脏中的山梨醇浓度。
结果
注射链脲佐菌素后的糖尿病大鼠出现高血糖（>1.7g·L-1）、多食、多尿、多饮及体重减轻。正常大鼠和糖尿病大鼠晶状体及坐骨神经中的山梨醇水平均升高；糖尿病大鼠升高更明显。血糖水平与山梨醇水平之间无相关性。糖尿病病程8个月后，小肠和肾脏中的山梨醇水平升高。
结论
晶状体和坐骨神经中的山梨醇水平随衰老而升高，糖尿病会加速这一过程。
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