中枢烟碱样受体上磷脂酰肌醇代谢的调节

Modulation of phosphatidylinositol turnover on central nicotinic receptors.

作者信息

Wang H, Lu X Q, Zhang Y F

机构信息

Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing, China.

出版信息

Zhongguo Yao Li Xue Bao. 1997 Jul;18(4):341-4.

PMID:10072918

Abstract

AIM

To study the modulatory effects of phosphatidylinositol (PI) turnover on nicotinic receptors in CNS, and to study the relationship between brain nicotinic receptors and PI turnover.

METHODS

Effects of inositol phosphatase inhibitor lithium chloride (LiCl) and muscarinic receptor agonist oxotremorine (Oxo) on nicotine-induced convulsions were investigated in mice.

RESULTS

The effects of nicotine for producing convulsions were modified by LiCl 2.5-10 mmol.kg-1, revealing the convulsive effects of nicotine > 0.8 mg.kg-1 were increased by acute pretreatment with LiCl rather than oxotremorine. Mice were given LiCl 5.0 mmol.kg-1 once a day for 7 d, the ED50 value of nicotine for producing convulsions was increased from 0.58 to 0.97 mg.kg-1, suggesting that the sensitivity of central nicotinic receptors for mediating convulsions was decreased by chronic treatment with LiCl.

CONCLUSION

The functions of central nicotinic receptors were modulated by PI turnover.

摘要

目的

研究磷脂酰肌醇（PI）代谢对中枢神经系统烟碱型受体的调节作用，以及脑烟碱型受体与PI代谢之间的关系。

方法

在小鼠中研究肌醇磷酸酶抑制剂氯化锂（LiCl）和毒蕈碱型受体激动剂氧化震颤素（Oxo）对尼古丁诱发惊厥的影响。

结果

2.5 - 10 mmol.kg-1的LiCl改变了尼古丁产生惊厥的作用，显示急性预处理LiCl而非氧化震颤素可增强尼古丁> 0.8 mg.kg-1的惊厥作用。小鼠每天给予5.0 mmol.kg-1的LiCl，持续7天，尼古丁产生惊厥的ED50值从0.58增加到0.97 mg.kg-1，表明长期给予LiCl可降低中枢烟碱型受体介导惊厥的敏感性。