氯胺酮诱导大鼠外周镇痛作用。
Ketamine-induced peripheral analgesia in rats.
作者信息
Bai L, Zhao Z Q
机构信息
Shanghai Brain Research Institute, Chinese Academy of Sciences, China.
出版信息
Zhongguo Yao Li Xue Bao. 1997 Jul;18(4):377-9.
AIM
To examine whether ketamine may directly act at peripheral nociceptors to produce analgesia.
METHODS
Wistar rats were anesthetized with urethane. As a nociceptive flexion reflex (FR), C responses from the posterior biceps semitendinosus (PBST) muscle was evoked by electrical stimulation (2 ms, 80 V, 2-3 pulses, 0.5 Hz) via a pair of stainless steel needles inserted subcutaneously applied to the two toes of ipsilateral hindpw.
RESULTS
Subcutaneous injection of ketamine (36 mmol.L-1, 5 microL) into the ipsilateral hindpaw produced an inhibition of C responses. At 9 min after application of ketamine, injection of naloxone (1%, 5 microL) into the same area annulled ketamine-induced inhibition.
CONCLUSION
Ketamine as a dissociate anesthetic acts on peripheral nociceptors to produce analgesia, which is related to activity of peripheral opioid receptors.
目的
研究氯胺酮是否可直接作用于外周伤害感受器产生镇痛作用。
方法
用乌拉坦麻醉Wistar大鼠。作为伤害性屈曲反射（FR），通过一对皮下插入的不锈钢针，对同侧后爪的两个脚趾施加电刺激（2毫秒，80伏，2 - 3个脉冲，0.5赫兹），诱发半腱肌后二头肌（PBST）肌肉的C反应。
结果
向同侧后爪皮下注射氯胺酮（36毫摩尔·升-1，5微升）可抑制C反应。在应用氯胺酮9分钟后，向同一区域注射纳洛酮（1%，5微升）可消除氯胺酮诱导的抑制作用。
结论
氯胺酮作为一种解离麻醉剂作用于外周伤害感受器产生镇痛作用，这与外周阿片受体的活性有关。
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