肾上腺素能受体激动剂可抑制大鼠星状神经节神经元中钙依赖性电位。
Adrenoceptor agonists inhibit calcium-dependent potentials in rat stellate ganglion neurons.
作者信息
Mo N, Li D
机构信息
Department of Pharmacology, Guangxi Medical College, Nanninq, China.
出版信息
Zhongguo Yao Li Xue Bao. 1997 Mar;18(2):124-7.
AIM
To study the effects of adrenoceptor agonists on the stellate ganglion neurons.
METHODS
Intracellular recordings were made from neurons of the isolated rat stellate ganglia.
RESULTS
Noradrenaline and clonidine (10-30 mumol.L-1) reversibly depressed 3 types of calcium-dependent potentials, namely, the action potential shoulder; the spike after-hyperpolarization; the Ca2+ spike evoked in Krebs' solution containing TTX and TEA and fast excitatory postsynaptic potential (f-EPSP).
CONCLUSION
The adrenoceptor agonists inhibitied the 3 calcium-dependent potentials; f-EPSP was inhibited by reducing Ca2+ influx at presynaptic site in population of neurons.
目的
研究肾上腺素能受体激动剂对星状神经节神经元的影响。
方法
对分离的大鼠星状神经节神经元进行细胞内记录。
结果
去甲肾上腺素和可乐定（10 - 30 μmol·L⁻¹）可逆性地抑制3种钙依赖性电位，即动作电位肩部、锋电位后超极化、在含TTX和TEA的 Krebs溶液中诱发的Ca²⁺锋电位以及快速兴奋性突触后电位（f-EPSP）。
结论
肾上腺素能受体激动剂抑制了3种钙依赖性电位；f-EPSP是通过减少神经元群体突触前部位的Ca²⁺内流而被抑制的。
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