组胺加重了豚鼠左甲状腺素诱导的心肌病。
Histamine aggravated levothyroxine-induced cardiomyopathy in guinea pigs.
作者信息
Hu H J, Dai D Z, Shen Y M
机构信息
Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing, China.
出版信息
Zhongguo Yao Li Xue Bao. 1997 Mar;18(2):159-60.
AIM
To study effects of histamine on cardiomyopathy.
METHODS
Cardiomyopathy model was developed in guinea pig by i.p. levothyroxine 0.5 mg.kg-1.d-1 for 10 d. Langendroff's hearts were perfused. ECG and contractile force were recorded. Histamine (5 micrograms) was given by intra-aortic injection. Histamine content of coronary venous effluent was determined fluorometrically.
RESULTS
Attack of histamine on cardiomyopathy was severer than that in normal hearts. Tachycardia was more prominent; atrioventricular conduction block occurred earlier; decrease in coronary flow was more marked. Uptakes of histamine were 37% in the model and 19% in the normal hearts (P < 0.01).
CONCLUSION
Histamine aggravated levothyroxine-cardiomyopathy.
目的
研究组胺对心肌病的影响。
方法
通过腹腔注射左甲状腺素0.5毫克/千克/天，持续10天，建立豚鼠心肌病模型。采用Langendroff法灌注心脏，记录心电图和收缩力。通过主动脉内注射给予组胺（5微克）。采用荧光法测定冠状静脉流出液中的组胺含量。
结果
组胺对心肌病心脏的攻击比对正常心脏更严重。心动过速更显著；房室传导阻滞出现更早；冠状动脉血流减少更明显。模型心脏对组胺的摄取率为37%，正常心脏为19%（P<0.01）。
结论
组胺加重了左甲状腺素所致的心肌病。
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