Jiang Z Q, Sun G M, Ma Y M
Department of Targeting Pharmaceutics, School of Pharmacy, Shanghai Medical University, China.
Zhongguo Yao Li Xue Bao. 1997 Mar;18(2):182-4.
To test an artificial reconstituted pulmonary surfactant (APS) for prevention and treatment of respiratory distress syndrome (RDS).
A membrane-formed method combined with supersonic dispersing was used to prepare APS. A pulsating bubble surface tension measurement was established to compare surface properties of APS with natural pulmonary surfactant (NPS). A preliminary clinical trial was made for prevention and treatment of RDS.
The APS reduced surface tension from 44.0 mN/m to < 1.0 mN/m in vitro. The changes of APS lipid contents were < 5% of labeled content at 37 degrees C. Clinical trial showed that the APS prevented RDS in 20/20 and cured RDS in 2/2 premature neonates.
The APS had good surface properties similar to NPS.
