Li X, Li J, Zhao S, Zhou Q, Gao M, Lu S
Department of cardiovascular Medicine, Second Affiliated Hospital, Hunan Medical University, Changsha.
Hunan Yi Ke Da Xue Xue Bao. 1997;22(5):387-9.
Using high resolution ultrasound, we measured the diameter of brachial arteries at rest, during reactive hyperemia and after glyceryl trinitrate (GTN) taking in 22 healthy persons. The results showed that brachial artery dilation was present both in reactive hyperemia and response to GTN. The mean flow-mediated dilation was 13.8 +/- 3.9% increment. The mean increment of dilation in response to GTN was 24.9 +/- 9.7%. The diameters of brachial arteries during reactive hyperemia and after sublingual GTN had significant difference compared with that in baseline (P < 0.01). It indicates that increased flow may mediate endothelium-dependent vessel dilatation and GTN cause endothelium-independent vessel dilatation in normal subjects. This paper presents a new non-invasive method of detecting endothelium-dependent dilation, which is proved to be simple, secure and practical.
我们使用高分辨率超声，测量了22名健康人静息时、反应性充血期间以及舌下含服硝酸甘油（GTN）后的肱动脉直径。结果显示，反应性充血和对GTN的反应中均出现肱动脉扩张。平均血流介导的扩张增加了13.8±3.9%。对GTN反应的平均扩张增加为24.9±9.7%。反应性充血期间和舌下含服GTN后的肱动脉直径与基线相比有显著差异（P<0.01）。这表明在正常受试者中，血流增加可能介导内皮依赖性血管扩张，而GTN引起非内皮依赖性血管扩张。本文提出了一种检测内皮依赖性扩张的新的非侵入性方法，该方法被证明简单、安全且实用。
