Li G, Sun M, Zhou H
Department of Medicine, Xiangya Hospital, Hunan Medical University, Changsha.
Hunan Yi Ke Da Xue Xue Bao. 1997;22(5):419-21, 424.
Thirty-three hypertensive patients with left ventricular hypertrophy were treated with slow-release verapamil for 1 year. The left ventricula mass index (LVMI) and the concentration of intracellular calcium ion ([Ca2+]i) of lymphocytes were studied respectively at the beginning, the third, the sixth and the twelveth month of treatment. The results revealed that: 1 the LVMI was positively correlated with [Ca2+]i and mean arterial pressure (MAP); 2 the LVMI, [Ca2+]i and MAP were significantly decreased, after treatment; 3 the degree of reduction of LVMI (delta LVMI) was positively correlated with the degree of lowering of [Ca2+]i (delta [Ca2+]i) and MAP (delta MAP); 4 the LVMI and [Ca2+]i showed no significant change at the third month but significant decrease at the sixth and twelveth month of treatment. It suggests that besides the decrease of MAP the decrease of [Ca2+]i is a significant factor for mechanism of regression of LVH.
33例左心室肥厚的高血压患者接受缓释维拉帕米治疗1年。分别在治疗开始时、第3个月、第6个月和第12个月研究左心室质量指数（LVMI）和淋巴细胞内钙离子浓度（[Ca2+]i）。结果显示：1. LVMI与[Ca2+]i及平均动脉压（MAP）呈正相关；2. 治疗后LVMI、[Ca2+]i和MAP均显著降低；3. LVMI降低程度（ΔLVMI）与[Ca2+]i降低程度（Δ[Ca2+]i）及MAP降低程度（ΔMAP）呈正相关；4. LVMI和[Ca2+]i在治疗第3个月无显著变化，但在第6个月和第12个月显著降低。这表明除MAP降低外，[Ca2+]i降低是LVH消退机制的一个重要因素。
