Lecoules S, Duvic C, Hérody M, Nédélec G
Clinique de Néphrologie, Hôpital d'Instruction des Armées du Val-de-Grâce, Paris.
Presse Med. 1999 Feb 13;28(6):273-5.
In the very large majority of cases, nephrotic syndrome with minimal glomerular lesions is an idiopathic condition. Drugs can favor the glomerulopathy. The effect of non-steroidal antiinflammatory drugs is well known, but other drugs, particularly tiopronin may be incriminated.
A 73-year-old patient developed severe nephrotic syndrome with minimal glomerular lesions 6 weeks after tiopronin therapy was initiated. Complete and spontaneous remission of the nephrotic syndrome was achieved 5 weeks after drug withdrawal. No recurrent lipoidic nephrosis has been observed at 3 years follow-up.
Tiopronin-induced nephrotic syndrome with minimal glomerular lesions is usually severe and develops rapidly. Remission occurs rapidly after drug withdrawal. Weekly urine checks with dip-strips should be proposed in patients treated with tiopronin.
在绝大多数情况下，微小病变型肾病综合征是一种特发性疾病。药物可促使肾小球病发生。非甾体抗炎药的作用已广为人知，但其他药物，尤其是硫普罗宁也可能与此有关。
一名73岁患者在开始硫普罗宁治疗6周后出现严重的微小病变型肾病综合征。停药5周后肾病综合征完全自发缓解。随访3年未观察到复发性脂质性肾病。
硫普罗宁诱发的微小病变型肾病综合征通常病情严重且发展迅速。停药后缓解迅速出现。对于接受硫普罗宁治疗的患者，应建议每周用试纸条进行尿液检查。
