扩张型心肌病所致心力衰竭中的运动诱导性血液浓缩

Exercise-induced hemoconcentration in heart failure due to dilated cardiomyopathy.

作者信息

Agostoni P, Wasserman K, Guazzi M, Cattadori G, Palermo P, Marenzi G, Guazzi M D

机构信息

Istituto di Cardiologia dell' Università degli Studi, Milan, Italy.

出版信息

Am J Cardiol. 1999 Jan 15;83(2):278-80, A6. doi: 10.1016/s0002-9149(98)00839-x.

DOI:10.1016/s0002-9149(98)00839-x

PMID:10073838

Abstract

Exercise-induced hemoconcentration is a useful mechanism, particularly in heart failure, because it increases oxygen content of blood, perfusing the working muscles; in 50 normal subjects and 50 patients with congestive heart failure, hemoglobin at peak exercise increased by 7 +/- 3% and 5 +/- 3%, respectively. Hemoconcentration was due to fluid flux out of the vascular bed, likely through oncotic forces related to intracellular lactate accumulation and not to red blood cell recruitment from other organs (spleen), because hemoglobin increase, as a percentage, was similar to plasma protein increase.

摘要

运动诱导的血液浓缩是一种有用的机制，尤其在心力衰竭中，因为它增加了血液的氧含量，为工作中的肌肉供血；在50名正常受试者和50名充血性心力衰竭患者中，运动峰值时的血红蛋白分别增加了7±3%和5±3%。血液浓缩是由于液体从血管床流出，可能是通过与细胞内乳酸积累相关的渗透力，而不是从其他器官（脾脏）募集红细胞，因为血红蛋白增加的百分比与血浆蛋白增加相似。