Yang Z, Liu J, Yan P, Liu Y, Li F
Institute of Hygiene and Environmental Medicine, Academy of Military Medical Sciences, Tianjin.
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 1997 Aug;13(3):235-7.
Several functions of vascular endothelial cells (VEC) were investigated in rats acclimated to cold (CA) and with frostbitten feet. The results indicated that in CA rats, the number of endothelial cells in circulatory blood and the contents of 6-keto -PGF1 alpha and TXB2 in plasma were markedly higher, the activity of serum angiotensin I converting enzyme (ACE) was lower, compared with those in rats non-acclimated to cold (NCA), whereas T/P ratio of the two groups was close to each other. After the rats were frostbitten, those parameters in NCA group increased sharply except for a decrease in ACE activity. But in CA group, those parameters decreased temporarily or did not change obviously and the tissue survival area (TSA) significantly increased. The above findings suggest that the adaptive changes in increase of metabolic turnover rate and function of VEC after cold acclimation may be beneficial to the body to enhance the resistance to frostbite and repairing ability.
对适应寒冷（CA）和足部冻伤的大鼠的血管内皮细胞（VEC）的几种功能进行了研究。结果表明，与未适应寒冷的大鼠（NCA）相比，CA大鼠循环血液中的内皮细胞数量以及血浆中6-酮-PGF1α和TXB2的含量明显更高，血清血管紧张素I转换酶（ACE）的活性更低，而两组的T/P比值彼此接近。大鼠冻伤后，NCA组的这些参数除ACE活性降低外均急剧增加。但在CA组中，这些参数暂时降低或无明显变化，组织存活面积（TSA）显著增加。上述结果表明，冷适应后VEC代谢周转率和功能增加的适应性变化可能有利于机体增强对冻伤的抵抗力和修复能力。
