Wei E, Zhang W, Lu Z, Wu R, Ju X, Bian R
Department of Pharmacology, Zhejiang Medical University, Hangzhou.
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 1997 Feb;13(1):86-8.
A simple, stable determining system in the conscious and unrestrained guinea pigs was established that can quantitatively analyse the airway reactivity (AR). In this model, the response to histamine (His) or acetylcholine (ACh) aerosol was concentration-dependent with EC50 effective concentration causing 50% animals wheezing) of 53.3 mumol/m3 and 269 mumol/m3 respectively.
建立了一种简单、稳定的清醒自由豚鼠测定系统，可定量分析气道反应性（AR）。在该模型中，对组胺（His）或乙酰胆碱（ACh）气雾剂的反应呈浓度依赖性，引起50%动物喘息的半数有效浓度（EC50）分别为53.3 μmol/m³和269 μmol/m³。
