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[大鼠腹主动脉血栓形成模型的建立与评价]

[The establishment and evaluation of abdominal aorta thrombosis model in rat].

作者信息

Xu H, Zhu M, Pei J, Zang Y, Han H

机构信息

Department of Physiology, 4th Military Medical University, Xian.

出版信息

Zhongguo Ying Yong Sheng Li Xue Za Zhi. 1997 Feb;13(1):89-90.

Abstract

An animal model of abdominal aorta thrombosis based on Virchow's thrombosis principle was induced by endothelium denudation with a polyethylene catheter combining severe stenosis with an aortic constriction in rats. A total of 37 rats were involved in thrombosis induction. Among them thrombus developed in 27 rats. Mean length of thrombus was 8.53 +/- 1.42 mm. The contractibility of vascular wall in the thrombotic group significantly reduced.

摘要

基于魏尔啸血栓形成原理,通过用聚乙烯导管剥脱内皮并结合大鼠主动脉严重狭窄与缩窄,诱导建立腹主动脉血栓形成的动物模型。共有37只大鼠参与血栓形成诱导。其中27只大鼠形成了血栓。血栓平均长度为8.53±1.42毫米。血栓形成组血管壁的收缩性显著降低。

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