免疫信号传导：SHP-2停靠在多个位点。
Immune signalling: SHP-2 docks at multiple ports.
作者信息
Huyer G, Alexander D R
机构信息
Laboratory of Lymphocyte Signalling and Development Molecular Immunology Programme The Babraham Institute Babraham Cambridge CB2 4AT UK.
出版信息
Curr Biol. 1999 Feb 25;9(4):R129-32. doi: 10.1016/s0960-9822(99)80080-3.
Abstract
The protein tyrosine phosphatase SHP-2 functions in many diverse signalling pathways. The recent identification of a SHP-2-binding protein as a homologue of the Grb2-associated adaptor protein Gab1 sheds light on the role of SHP-2 in immune signalling.
摘要
蛋白质酪氨酸磷酸酶SHP-2在多种不同的信号通路中发挥作用。最近鉴定出一种SHP-2结合蛋白，它是Grb2相关衔接蛋白Gab1的同源物，这为SHP-2在免疫信号传导中的作用提供了线索。
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