肌动蛋白聚合：WASP的“蛰刺”之处。
Actin polymerization: Where the WASP stings.
作者信息
Bi E, Zigmond S H
机构信息
Departments of Cell and Developmental Biology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6018, USA.
出版信息
Curr Biol. 1999 Mar 11;9(5):R160-3. doi: 10.1016/s0960-9822(99)80102-x.
Abstract
How do extracellular signals induce actin polymerization, as required for many cellular responses? Key signal transducers, such as the small GTPases Cdc42 and Rac, have now been shown to link via proteins of the WASP family to the Arp2/3 complex, which nucleates actin polymerization.
摘要
细胞外信号如何像许多细胞反应所要求的那样诱导肌动蛋白聚合呢？关键信号转导分子，如小GTP酶Cdc42和Rac，现已证明可通过WASP家族的蛋白质与Arp2/3复合体相连，该复合体可引发肌动蛋白聚合。
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