离子通道：一种分子制动器的结构
Ion channels: structure of a molecular brake.
作者信息
Sansom M S
机构信息
Laboratory of Molecular Biophysics, Department of Biochemistry, The University of Oxford, The Rex Richards Building, South Parks Road, Oxford OX1 3QU, UK.
出版信息
Curr Biol. 1999 Mar 11;9(5):R173-5. doi: 10.1016/s0960-9822(99)80106-7.
Abstract
A combination of crystallographic and mutagenesis studies on the HERG K+ channel, a key determinant of cardiac excitability, has suggested how the protein's extramembraneous amino-terminal domain might act as a 'molecular brake' that slows down channel deactivation.
摘要
对心脏兴奋性的关键决定因素HERG钾通道进行的晶体学和诱变研究相结合，揭示了该蛋白的膜外氨基末端结构域可能如何作为一种“分子刹车”来减缓通道失活。
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