高压氧治疗对辐照大鼠骨中羟基磷灰石植入物周围愈合影响的组织形态计量学评估

Histomorphometric evaluation of the effect of hyperbaric oxygen treatment on healing around hydroxyapatite implants in irradiated rat bone.

作者信息

Chen X, Matsui Y, Ohno K, Michi K

机构信息

First Department of Oral and Maxillofacial Surgery, Showa University, School of Dentistry, Tokyo, Japan.

出版信息

Int J Oral Maxillofac Implants. 1999 Jan-Feb;14(1):61-8.

PMID:10074753

Abstract

The effect of hyperbaric oxygen (HBO) on the tissue reaction around hydroxyapatite (HA) implants in irradiated bone of rats was investigated. A single dose of 15 Gy was delivered to the right leg of 20 rats. HA implants were placed in the bilateral tibial proximal metaphysis 3 months after irradiation. HBO was administered to half of the rats before and after 15-Gy irradiation. The healing process was examined histologically and histomorphometrically. The results indicated that HBO slightly improved trabecular bone formation in the irradiated bone, accelerated bone remodeling in the nonirradiated bone, and improved HA-bone contact in both the irradiated and nonirradiated bones.

摘要

研究了高压氧（HBO）对大鼠受辐照骨中羟基磷灰石（HA）植入物周围组织反应的影响。对20只大鼠的右腿给予单次15 Gy的辐射剂量。在辐照3个月后，将HA植入物置于双侧胫骨近端干骺端。对一半的大鼠在15 Gy辐照前后给予HBO治疗。通过组织学和组织形态计量学检查愈合过程。结果表明，HBO略微改善了受辐照骨中的小梁骨形成，加速了未受辐照骨中的骨重塑，并改善了受辐照和未受辐照骨中的HA与骨的接触。