Tesoro M R, Borgida A F, MacLaurin N A, Asuncion C M
Department of Obstetrics and Gynecology, Saint Francis Hospital and Medical Center, Hartford, Connecticut 06105, USA.
Obstet Gynecol. 1999 Mar;93(3):363-6. doi: 10.1016/s0029-7844(98)00418-9.
To evaluate sonographic measurements of endometrial thickness in postmenopausal women taking adjuvant tamoxifen therapy for breast cancer, and to correlate sonographic and pathologic findings to symptoms and duration of tamoxifen therapy.
Medical records and sonograms of 80 postmenopausal women treated for breast cancer with adjuvant tamoxifen therapy were reviewed retrospectively. Endometrial thickness was recorded as a single-layer thickness and considered abnormal when greater than 2.5 mm for postmenopausal women. Sonographic endometrial thickness was correlated to histologic findings, symptoms, and duration of tamoxifen therapy.
Fifty-seven of 80 postmenopausal women (69%) had single-layer endometrial thicknesses of 2.5 mm or greater, measured by transvaginal sonography, and 55 of 57 had endometrial biopsies or dilatations and curettage. Biopsies detected 24 cases of abnormal endometria, including endometrial carcinoma (two), breast carcinoma metastatic to the endometrium (one), endometrial polyps (13), tubal metaplasia (three), and benign endometrial hyperplasia (five). Using a single-layer endometrial thickness greater than 2.5 mm by transvaginal ultrasound, 21 of 24 (87.5%) women with abnormal endometria were detected. Women with abnormal pathologic findings had a significantly thicker mean single-layer endometrial thickness than those with normal findings, 7 mm versus 4 mm (P < .01). Twelve women had postmenopausal bleeding, all of whom had a single-layer endometrial thickness greater than 2.5 mm on transvaginal sonography.
With a sensitivity of detecting endometrial abnormalities of 84%, transvaginal sonography was useful for studying postmenopausal tamoxifen-treated women.
评估接受辅助性他莫昔芬治疗乳腺癌的绝经后女性的子宫内膜厚度超声测量值，并将超声和病理结果与他莫昔芬治疗的症状及疗程相关联。
回顾性分析80例接受辅助性他莫昔芬治疗乳腺癌的绝经后女性的病历和超声检查结果。子宫内膜厚度记录为单层厚度，绝经后女性单层厚度大于2.5 mm时视为异常。超声子宫内膜厚度与组织学结果、症状及他莫昔芬治疗疗程相关联。
80例绝经后女性中，57例（69%）经阴道超声测量单层子宫内膜厚度为2.5 mm或更大，57例中的55例进行了子宫内膜活检或刮宫术。活检发现24例子宫内膜异常，包括子宫内膜癌（2例）、子宫内膜转移性乳腺癌（1例）、子宫内膜息肉（13例）、输卵管化生（3例）和良性子宫内膜增生（5例）。经阴道超声单层子宫内膜厚度大于2.5 mm时，24例子宫内膜异常女性中有21例（87.5%）被检测出。病理结果异常的女性平均单层子宫内膜厚度显著厚于结果正常的女性，分别为7 mm和4 mm（P <.01）。12例女性出现绝经后出血，所有这些女性经阴道超声检查单层子宫内膜厚度均大于2.5 mm。
经阴道超声检测子宫内膜异常的敏感性为84%，对研究接受他莫昔芬治疗的绝经后女性有用。
