Chromosomal clues to the development of prostate tumors.
作者信息
Brothman A R, Maxwell T M, Cui J, Deubler D A, Zhu X L
机构信息
Department of Pediatrics, University of Utah School of Medicine, Salt Lake City 84132, USA.
出版信息
Prostate. 1999 Mar 1;38(4):303-12. doi: 10.1002/(sici)1097-0045(19990301)38:4<303::aid-pros6>3.0.co;2-e.
BACKGROUND
Cytogenetic, molecular cytogenetic, and molecular studies of prostate cancer have revealed an enormous amount of data regarding chromosomal loci that are aberrant in prostate tumors.
METHODS
These data have been compared and condensed in this review to determine which chromosomes and chromosome sites have been most frequently reported.
RESULTS
Loss of the Y chromosome, gain of 7, 8, and X, and interstitial deletions on 6q, 7q, 8p, 10q, 13q, 16q, 17q, and 18q are the most prevalent.
CONCLUSIONS
A potential model for genetic control of tumor progression is presented, as are data regarding the evaluation of a new series of tumors.
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