Luborsky J, Llanes B, Davies S, Binor Z, Radwanska E, Pong R
Reproductive Endocrinology and Infertility Section, Department of Obstetrics and Gynecology, Rush Medical College, Chicago, Illinois 60612, USA.
Clin Immunol. 1999 Mar;90(3):368-74. doi: 10.1006/clim.1998.4661.
The objective of this study was to: (1) assess the relative prevalence of ovarian, thyroid, nuclear, and cardiolipin antibodies associated with premature menopause and unexplained infertility and (2) compare ovarian and thyroid antibodies in premature menopause, unexplained infertility, and the general population. Autoantibodies were evaluated in women with premature menopause (n = 30), unexplained infertility with (n = 38) or without (n = 15) prior gonadotropin-induced ovulation, and normal cycling controls (n = 12) and in a population of women obtained from a blood bank (n = 53). Antibodies to ovary (OVAB), thyroid (THYAB; thyroid peroxidase and thyroglobulin), cardiolipin, and eight nuclear antigens were assessed by enzyme immunoassay. Organ-specific antibodies (ovary and thyroid) were present with significantly greater frequency than non-organ-specific antibodies (nuclear and cardiolipin) in premature menopause and unexplained infertility (60% (50/83) vs 16% (13/83) respectively; P < 0.0001). OVAB (53%, 44/83) were significantly more frequent than THYAB (30%, 25/83) in premature menopause and unexplained infertility (P = 0.0030). THYAB did not differ among all groups (P = 0.78). In premature menopause and treated or untreated unexplained infertility OVAB frequencies were 53, 61, and 33%, respectively, and were significantly more frequent than in the population (17%) (P = 0.0001). In unexplained infertility, individuals with no prior gonadotropin-induced ovulation had a lower frequency of OVAB than treated individuals (P = 0.07). The frequency distribution of optical density values for OVAB was significantly higher for premature menopause and unexplained infertility than for population or normal cycling women (P < 0.0001). Thus, only ovarian antibodies were significantly more frequent than other antibody markers of autoimmunity in premature menopause and unexplained infertility.
（1）评估与早发性绝经和不明原因不孕症相关的卵巢、甲状腺、核抗原和心磷脂抗体的相对患病率；（2）比较早发性绝经、不明原因不孕症和普通人群中的卵巢抗体和甲状腺抗体。对早发性绝经女性（n = 30）、有（n = 38）或无（n = 15）既往促性腺激素诱导排卵的不明原因不孕症女性、正常月经周期对照组（n = 12）以及从血库获取的女性群体（n = 53）的自身抗体进行了评估。通过酶免疫测定法评估卵巢抗体（OVAB）、甲状腺抗体（THYAB；甲状腺过氧化物酶和甲状腺球蛋白）、心磷脂抗体以及八种核抗原抗体。在早发性绝经和不明原因不孕症中，器官特异性抗体（卵巢和甲状腺）的出现频率显著高于非器官特异性抗体（核抗原和心磷脂）（分别为60%（50/83）和16%（13/83）；P < 0.0001）。在早发性绝经和不明原因不孕症中，OVAB（53%，44/83）的出现频率显著高于THYAB（30%，25/83）（P = 0.0030）。THYAB在所有组中无差异（P = 0.78）。在早发性绝经以及经治疗或未经治疗的不明原因不孕症中，OVAB的频率分别为53%、61%和33%，显著高于普通人群（17%）（P = 0.0001）。在不明原因不孕症中，既往无促性腺激素诱导排卵的个体中OVAB的频率低于经治疗的个体（P = 0.07）。早发性绝经和不明原因不孕症中OVAB光密度值的频率分布显著高于普通人群或正常月经周期女性（P < 0.0001）。因此，在早发性绝经和不明原因不孕症中，只有卵巢抗体的出现频率显著高于其他自身免疫抗体标志物。
