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酵母线粒体非选择性通道活性对呼吸链的依赖性。

Dependence of yeast mitochondrial unselective channel activity on the respiratory chain.

作者信息

Manon S

机构信息

Institut de Biochimie et de Génétique Cellulaires du CNRS, 1 rue Camille Saint-Saëns, F-33077, Bordeaux cedex, France.

出版信息

Biochim Biophys Acta. 1999 Jan 27;1410(1):85-90. doi: 10.1016/s0005-2728(98)00178-9.

DOI:10.1016/s0005-2728(98)00178-9
PMID:10076018
Abstract

The dependence of yeast mitochondrial unselective channel activity on the respiratory chain was investigated. Modulation of the respiratory chain with different substrates and inhibitors showed that channel activity was dependent on the electron flow rate through the chain and that external NADH only could provide a sufficient rate to activate the channel. These results support the hypothesis that the yeast mitochondrial unselective channel may be involved in the oxidation of cytosolic NADH without coupling to ATP synthesis.

摘要

研究了酵母线粒体非选择性通道活性对呼吸链的依赖性。用不同底物和抑制剂对呼吸链进行调节表明，通道活性依赖于通过呼吸链的电子流速率，并且只有胞外NADH能够提供足够的速率来激活该通道。这些结果支持以下假说：酵母线粒体非选择性通道可能参与胞质NADH的氧化，而不与ATP合成相偶联。

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