Roy-Clavel E, Picard S, St-Louis J, Brochu M
Centre de Recherche, Hôpital Sainte-Justine, Montreal, Quebec, Canada.
Am J Obstet Gynecol. 1999 Mar;180(3 Pt 1):608-13. doi: 10.1016/s0002-9378(99)70262-0.
A low-sodium diet fed to female rats before mating through parturition leads to pups of lower weight. We characterized the effect of low dietary sodium during the last week of gestation (after fetal organogenesis) on fetal and maternal homeostasis.
Pregnant Sprague-Dawley rats were randomly assigned to a control group or to a group fed a low-sodium diet from gestational days 15 through 22. Systolic blood pressures were measured throughout pregnancy. On day 22 plasma volume was measured and blood samples were taken for electrolyte and hormonal measurements. Fetal and placental weights were also determined.
Plasma renin activity and aldosterone level were significantly higher in the experimental group than in the control group. Plasma volume was significantly lower in pregnant rats receiving a low-sodium than in those receiving a control diet. Rats receiving a low-sodium diet had pups of lower weight and length (4.45 +/- 0.22 g, 3.90 +/- 0.06 cm) than pups of the control group (5.21 +/- 0.12 g, 4.10 +/- 0.02 cm). Pups born to mothers with low-sodium diets recuperated from intrauterine growth restriction by 14 days after birth.
These data indicate that a low-sodium diet given to pregnant rats for the last 7 days of gestation leads to reduced plasma volume expansion and fetal growth restriction. This could prove to be a simple animal model for studying the relationship between maternal plasma volume and fetal growth.
在雌性大鼠交配前至分娩期间给予低钠饮食会导致幼崽体重较轻。我们研究了妊娠最后一周（胎儿器官形成后）低钠饮食对胎儿和母体稳态的影响。
将怀孕的斯普拉格 - 道利大鼠随机分为对照组或从妊娠第15天至22天给予低钠饮食的组。在整个孕期测量收缩压。在第22天测量血浆容量，并采集血样进行电解质和激素测量。还测定了胎儿和胎盘的重量。
实验组的血浆肾素活性和醛固酮水平显著高于对照组。接受低钠饮食的怀孕大鼠的血浆容量显著低于接受对照饮食的大鼠。接受低钠饮食的大鼠所产幼崽的体重和体长（4.45±0.22克，3.90±0.06厘米）低于对照组幼崽（5.21±0.12克，4.10±0.02厘米）。低钠饮食组母鼠所生幼崽在出生后14天从宫内生长受限中恢复过来。
这些数据表明，在妊娠最后7天给予怀孕大鼠低钠饮食会导致血浆容量扩张减少和胎儿生长受限。这可能是一个用于研究母体血浆容量与胎儿生长之间关系的简单动物模型。
