Gonschorek A S, Feistner H, Awiszus F
Department of Clinical Neurophysiology, Otto-von-Guericke University Magdeburg.
Electromyogr Clin Neurophysiol. 1999 Jan-Feb;39(1):27-32.
Responses of single tibialis anterior motor units to transcranial magnetic stimulation and to a synchronized Ia volley evoked by peripheral electrical nerve stimulation were obtained in patients with distal spinal muscular atrophy and compared to normal controls. Estimations of excitatory postsynaptic potential (EPSPs) by cross-correlations revealed no difference in rise time of EPSPs for both groups of subjects despite considerable changes in macro-EMG parameters of the motor units studied in patients with spinal muscular atrophy (SMA). The results indicate that voluntarily activated spinal motoneurons in SMA are capable of normal excitatory responses to transcranial magnetic as well as peripheral Ia stimulation.
在远端脊髓性肌萎缩症患者中获得了单个胫前运动单位对经颅磁刺激以及外周电神经刺激诱发的同步Ia群集的反应，并与正常对照组进行了比较。通过互相关分析对兴奋性突触后电位（EPSP）进行估计，结果显示，尽管脊髓性肌萎缩症（SMA）患者所研究运动单位的宏肌电图参数有相当大的变化，但两组受试者的EPSP上升时间并无差异。结果表明，SMA中自主激活的脊髓运动神经元对经颅磁刺激以及外周Ia刺激能够产生正常的兴奋性反应。
