脊髓灰质炎病毒及其细胞受体：病毒/受体亲和力相互作用的分子遗传学剖析

Poliovirus and its cellular receptor: a molecular genetic dissection of a virus/receptor affinity interaction.

作者信息

Solecki D, Gromeier M, Harber J, Bernhardt G, Wimmer E

机构信息

Department of Molecular Genetics and Microbiology, School of Medicine, State University of New York at Stony Brook 11974, USA.

出版信息

J Mol Recognit. 1998 Winter;11(1-6):2-9. doi: 10.1002/(SICI)1099-1352(199812)11:1/6<2::AID-JMR380>3.0.CO;2-D.

DOI:10.1002/(SICI)1099-1352(199812)11:1/6<2::AID-JMR380>3.0.CO;2-D

PMID:10076797

Abstract

The ability of a virus to attach to a susceptible host cell is of utmost importance for the initiation of viral life cycle. Cell surface proteins called viral receptors mediate the initial steps of virus attachment and uptake. Poliovirus (PV) is one of the most studied animal viruses and its interaction with its cellular receptor, the human poliovirus receptor (hPVR) has been well characterized. This review will present our current understanding of the PV/hPVR interaction at the genetic and biochemical level. In addition, we will also discuss the implications of the PV/hPVR interaction on PV tissue tropism and the evolution of the three PV serotypes.

摘要

病毒附着于易感宿主细胞的能力对于病毒生命周期的启动至关重要。称为病毒受体的细胞表面蛋白介导病毒附着和摄取的初始步骤。脊髓灰质炎病毒（PV）是研究最多的动物病毒之一，其与细胞受体人脊髓灰质炎病毒受体（hPVR）的相互作用已得到充分表征。本综述将阐述我们目前在遗传和生化水平上对PV/hPVR相互作用的理解。此外，我们还将讨论PV/hPVR相互作用对PV组织嗜性和三种PV血清型进化的影响。