Montalbán C, García-Unzueta M T, De Francisco A L, Amado J A
Endocrinology Unit, University Hospital Marqués de Valdecilla, Santander, Spain.
Horm Metab Res. 1999 Jan;31(1):14-7. doi: 10.1055/s-2007-978689.
Interleukin-6, synthesized by osteoblasts in response to PTH, stimulates osteoclastogenesis and bone resorption in vitro, and it has been implicated in the pathogenesis of bone loss in several clinical situations. The aim of this study was to evaluate whether serum levels of interleukin-6 were increased in patients with renal osteodystrophy, and to investigate the possible relationships between serum interleukin-6 and PTH levels on one hand, and serum interleukin-6 and bone remodeling markers on the other. Serum interleukin-6 (IL-6), intact PTH, osteocalcin, bone alkaline phosphatase (BAP) and carboxyterminal telopeptide of Type 1 collagen (ICTP) were measured in 86 uremic patients. IL-6 (median [range] 16.5 [1.0-430] pg/ml), PTH (279.8 [11-2004] pg/ml), osteocalcin (143.8 [8-921] ng/ml), BAP (20.9 [6-169] U/I) and ICTP (38.8 [1.5-181.5] microg/l) were higher than normal. IL-6 levels correlated with PTH (r= 0.22, p = 0.04) and with ICTP (r = 0.31, p = 0.004). A stronger correlation was found between PTH and circulating bone remodeling markers (r = 0.66 for osteocalcin, r = 0.56 for BAP, and r = 0.39 for ICTP). The correlation between PTH and IL-6 was stronger in those patients (n = 15) with severe secondary hyperparathyroidism (r= 0,71, p = 0.003). On the other hand, in the group of patients (n = 41) with PTH lower than 250 pg/ml, there was no correlation between IL-6 and PTH, while IL-6 correlated with ICTP (r = 0.44, p = 0.006). Serum IL-6 correlates with ICTP which suggests that it may mediate bone resorption in renal osteodystrophy.
成骨细胞响应甲状旁腺激素（PTH）合成的白细胞介素-6，在体外刺激破骨细胞生成和骨吸收，并且在几种临床情况下与骨质流失的发病机制有关。本研究的目的是评估肾性骨营养不良患者血清白细胞介素-6水平是否升高，并一方面研究血清白细胞介素-6与PTH水平之间的可能关系，另一方面研究血清白细胞介素-6与骨重塑标志物之间的可能关系。测定了86例尿毒症患者的血清白细胞介素-6（IL-6）、完整PTH、骨钙素、骨碱性磷酸酶（BAP）和I型胶原羧基末端肽（ICTP）。IL-6（中位数[范围]16.5[1.0 - 430]pg/ml）、PTH（279.8[11 - 2004]pg/ml）、骨钙素（143.8[8 - 921]ng/ml）、BAP（20.9[6 - 169]U/I）和ICTP（38.8[1.5 - 181.5]μg/l）高于正常水平。IL-6水平与PTH（r = 0.22，p = 0.04）和ICTP（r = 0.31，p = 0.004）相关。在PTH与循环骨重塑标志物之间发现更强的相关性（骨钙素r = 0.66，BAP r = 0.56，ICTP r = 0.39）。在那些患有严重继发性甲状旁腺功能亢进的患者（n = 15）中，PTH与IL-6之间的相关性更强（r = 0.71，p = 0.003）。另一方面，在PTH低于250 pg/ml的患者组（n = 41）中，IL-6与PTH之间无相关性，而IL-6与ICTP相关（r = 0.44，p =
