17-α-雌二醇对低密度脂蛋白氧化的抑制作用。
The inhibition of low density lipoprotein oxidation by 17-alpha estradiol.
作者信息
Dittrich R, Müller A, Hensen J, Wildt L
机构信息
Dept. of Obstetrics and Gynaecology, University of Erlangen-Nuremberg, Erlangen, Germany.
出版信息
Exp Clin Endocrinol Diabetes. 1999;107(1):53-7. doi: 10.1055/s-0029-1212073.
The inhibition of LDL-oxidation by 17-alpha estradiol was assessed in vitro by the determination of the duration of the lag-phase in copper ion-induced oxidation and compared to that of 17-beta estradiol, estriol, and probucol. Addition of 0.2, 0.4, and 1 micromol/l of the test substances prolonged the lag-phase of LDL-oxidation 1.3-(+/-0.09 SD), 1.7-(+/-0.14 SD), and 2.7-(+/-0.25 SD) fold for 17-alpha estradiol; 1.4-(+/-0.14 SD), 1.8-(+/-0.1 SD), and 2.6-(+/-0.16 SD) fold for 17-beta estradiol; 1.1-(+/-0.07 SD), 1.4-(+/-0.11 SD), and 1.6-(+/-0.11 SD) fold for estriol as well as 1.4-(+/-0.14 SD), 1.6-(+/-0.1 SD), and 3.0-(+/-0.21) fold for probucol, thus proving that 17-alpha estradiol is as effective as 17-beta estradiol or similar to probucol and more effective than estriol (n = 6 in all cases). These data demonstrate that 17-alpha estradiol is able to delay LDL-oxidation, hence providing a basis for clinical examination of the protective effects of 17-alpha estradiol against atherosclerosis in patients where hormonal effects of 17-beta estradiol are undesirable.
通过测定铜离子诱导氧化过程中滞后期的持续时间，在体外评估了17-α雌二醇对低密度脂蛋白（LDL）氧化的抑制作用，并与17-β雌二醇、雌三醇和普罗布考进行了比较。添加0.2、0.4和1微摩尔/升的受试物质后，17-α雌二醇使LDL氧化的滞后期延长了1.3倍（±0.09标准差）、1.7倍（±0.14标准差）和2.7倍（±0.25标准差）；17-β雌二醇分别延长了1.4倍（±0.14标准差）、1.8倍（±0.1标准差）和2.6倍（±0.16标准差）；雌三醇分别延长了1.1倍（±0.07标准差）、1.4倍（±0.11标准差）和1.6倍（±0.11标准差）；普罗布考分别延长了1.4倍（±0.14标准差）、1.6倍（±0.1标准差）和3.0倍（±0.21标准差），从而证明17-α雌二醇与17-β雌二醇效果相当或与普罗布考相似，且比雌三醇更有效（所有情况下n = 6）。这些数据表明，17-α雌二醇能够延缓LDL氧化，因此为临床研究17-α雌二醇在17-β雌二醇激素作用不理想的患者中对动脉粥样硬化的保护作用提供了依据。
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