Shimazawa R, Miyachi H, Takayama H, Kuroda K, Kato F, Kato M, Hashimoto Y
Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
Biol Pharm Bull. 1999 Feb;22(2):224-6. doi: 10.1248/bpb.22.224.
Recently, we developed novel tumor necrosis factor (TNF)-alpha production regulators with a phthalimide skeleton derived from thalidomide. We show here that some of these compounds are more potent inhibitors than thalidomide of angiogenesis induced by basic fibroblast growth factor in a murine angiogenesis assay.
