Fischbach W
Klinikum Aschaffenburg, 11 Mediziniske Klinik, Amhasen Kope, Germany.
Ital J Gastroenterol Hepatol. 1998 Oct;30 Suppl 3:S299-303.
Primary gastric lymphoma of mucosa associated lymphoid tissue represent a distinct entity which is documented by their own histological classification. Our knowledge about all aspects of these lymphoma has substantially increased during the last few years. Epidemiological, histomorphological, molecular-biological and experimental data clearly underline that Helicobacter pylori infection of the gastric mucosa without doubt plays an important role both in the development and progression of MALT lymphoma. Considering histological malignancy (low grade and high grade lymphoma) and dissemination of the disease (stage) as decisive prognostic factors and therapeutical determinants, endoscopic bioptic diagnosis as well as endoscopic ultrasound are of major importance in establishing diagnosis and clinical stage. In the case of localized low grade lymphoma, eradication of Helicobacter pylori offers a promising therapeutic option. Surgical resection and radiochemotherapy have proven to be effective treatment modalities. There is a need for randomised trials to establish whether operative or conservative therapeutic strategies have to be favoured in the future.
黏膜相关淋巴组织原发性胃淋巴瘤是一种独特的实体，有其自身的组织学分类作为依据。在过去几年里，我们对这些淋巴瘤各方面的认识有了显著提高。流行病学、组织形态学、分子生物学和实验数据清楚地表明，胃黏膜的幽门螺杆菌感染无疑在MALT淋巴瘤的发生和发展中都起着重要作用。将组织学恶性程度（低级别和高级别淋巴瘤）以及疾病的播散情况（分期）视为决定性的预后因素和治疗决定因素，内镜活检诊断以及内镜超声在确立诊断和临床分期方面至关重要。对于局限性低级别淋巴瘤，根除幽门螺杆菌提供了一种有前景的治疗选择。手术切除和放化疗已被证明是有效的治疗方式。需要进行随机试验来确定未来是更倾向于手术还是保守治疗策略。
