Kawasaki S, Matsushima K
Department of Hygiene and Molecular Preventive Medicine, School of Medicine, University of Tokyo.
Nihon Rinsho. 1999 Feb;57(2):278-82.
The chemokine is a new class of cytokine. Now, more than 30 members of chemokine superfamily and 15 members of chemokine receptors (CXCR1-4, CCR1-8, CX3CR, CCR) have been identified. They were shown to be involved in the inflammatory response. The chemokine is classified into four subgroups (CXC, CC, C and CX3C). The local production of IL-8, MCP-1 and RANTES in rheumatoid inflamed joints has been reported. The predominance of several chemokines in other collagen diseases, such as SLE, systemic sclerosis and myositis is also described. Therefore, the inhibition of chemokines or chemokine receptors might be novel targets for various human disease, including collagen diseases.
趋化因子是一类新的细胞因子。目前，已鉴定出趋化因子超家族的30多个成员和趋化因子受体（CXCR1 - 4、CCR1 - 8、CX3CR、CCR）的15个成员。它们被证明参与炎症反应。趋化因子分为四个亚组（CXC、CC、C和CX3C）。已有报道类风湿性炎症关节中白细胞介素 - 8、单核细胞趋化蛋白 - 1和调节激活正常T细胞表达和分泌因子在局部产生。也描述了几种趋化因子在其他胶原病如系统性红斑狼疮、系统性硬化症和肌炎中的优势。因此，抑制趋化因子或趋化因子受体可能是包括胶原病在内的各种人类疾病的新靶点。
