Tada Y, Nagasawa K
Department of Internal Medicine, Saga Medical School.
Nihon Rinsho. 1999 Feb;57(2):419-24.
Non-steroidal antiinflammatory drugs (NSAID) are widely used for the treatment of rheumatoid arthritis and other collagen vascular diseases, and now more than 30 drugs are available. However, caution should be paid in using NSAIDs because of their serious side effects, especially gastrointestinal toxicity. Misoprostol has been shown to prevent NSAID-induced gastrointestinal damage, and proton-pump inhibitor omeprazole and misoprostol have been shown to be effective in the treatment of ulcers and erosions induced by NSAIDs. After the discovery of cyclooxygenase-2 (COX-2), investigators have raised a hypothesis that specific inhibitor of COX-2 should have anti-inflammatory activity with least gastrointestinal toxicity. According to this, efforts have been paid to produce COX-2 selective inhibitors. Although several COX-2 inhibitors have been reported to show reduced toxicity, further investigations are needed to establish their usefulness.
非甾体抗炎药（NSAID）被广泛用于治疗类风湿性关节炎和其他胶原血管疾病，目前有30多种此类药物可供使用。然而，由于其严重的副作用，尤其是胃肠道毒性，在使用NSAID时应谨慎。已证明米索前列醇可预防NSAID引起的胃肠道损伤，质子泵抑制剂奥美拉唑和米索前列醇已被证明对治疗NSAID引起的溃疡和糜烂有效。在发现环氧化酶-2（COX-2）后，研究人员提出了一个假设，即COX-2的特异性抑制剂应具有抗炎活性且胃肠道毒性最小。据此，人们致力于生产COX-2选择性抑制剂。尽管有报道称几种COX-2抑制剂显示出较低的毒性，但仍需要进一步研究以确定其效用。
