Iwasaki T, Saitou Y, Wada Y, Ishiai S, Ishii K
Department of Neurology, Tokyo Medical and Dental University.
Rinsho Shinkeigaku. 1998 Sep;38(9):801-5.
A 69-year-old women was admitted to Tokyo Medical and Dental University Hospital because of slowly progressive difficulty in speech production over 8-years. On admission, her spontaneous speech was non-fluent, limited to one-syllable utterance, and severely efforty. But her visual and auditory comprehension was preserved. There was no significant general intellectual deterioration. Severe buccofacial apraxia, but no swallowing was observed. So we considered her difficulty in speech as aphemia. Three-dimensionally reconstructed surface MR image clearly showed severe atrophy in the posterior part of the left inferior frontal gyrus and the lower part of the left pre-central gyrus. The FDG-PET demonstrated a focal hypometabolism in the same region. The lesion in this area was suggested to be a cause of speech production difficulty in this case.
一名69岁女性因8年来逐渐出现的言语产生困难而入住东京医科齿科大学医院。入院时，她的自发言语不流畅，仅限于单音节发声，且极为费力。但她的视觉和听觉理解能力保留。无明显的整体智力衰退。存在严重的口面部失用，但未观察到吞咽障碍。因此，我们认为她的言语困难为运动性缄默症。三维重建表面磁共振图像清晰显示左侧额下回后部和左侧中央前回下部严重萎缩。氟代脱氧葡萄糖正电子发射断层显像（FDG-PET）显示同一区域有局灶性代谢减低。该区域的病变被认为是本例言语产生困难的原因。
