Szabó G, Jakab F, Mihály K, Szentirmai A
Acta Hepatogastroenterol (Stuttg). 1976 Nov-Dec;23(6):415-22.
The biliaro-lymphatic reflux of bilirubin and bile salts is present in the dog only in the first 24 hrs of complete biliary obstruction. The reflux has been demonstrated also in rats, but it is absent in dogs with functioning gall bladder, when bile pressure does not attain the "secretory pressure". Alkaline phosphatase and GOT do not regurgitate in bile stasis into the lymph. The biliaro-lymphatic reflux of bile pigments and bile salts stops in consequence of the cessation of their secretion into the bile. This is corroborated by the observation that in the rat the excretion of BSP into the bile ceases after a prolonged bile stasis. The uptake by the hepatocytes of BSP and other substances does not stop, however, after several days of complete biliary obstruction. The bile constuents are released in prolonged bile stasis from the liver cells directly into the sinusoidal blood. This is probably the consequence of some damage of the cell function.
胆红素和胆盐的胆-淋巴反流仅在犬完全性胆道梗阻的最初24小时内出现。这种反流在大鼠中也得到了证实，但在胆囊功能正常、胆汁压力未达到“分泌压力”的犬中不存在。碱性磷酸酶和谷草转氨酶在胆汁淤积时不会反流至淋巴中。由于胆汁色素和胆盐停止分泌至胆汁中，其胆-淋巴反流也随之停止。这一点得到了如下观察结果的证实：在大鼠中，长时间胆汁淤积后，BSP向胆汁中的排泄停止。然而，在完全性胆道梗阻数天后，肝细胞对BSP和其他物质的摄取并未停止。在长时间胆汁淤积时，胆汁成分直接从肝细胞释放至肝血窦中。这可能是细胞功能受到某种损害的结果。
