Dobroszycki J, Herwaldt B L, Boctor F, Miller J R, Linden J, Eberhard M L, Yoon J J, Ali N M, Tanowitz H B, Graham F, Weiss L M, Wittner M
Department of Pediatrics, Bronx-Lebanon Hospital Center, NY, USA.
JAMA. 1999 Mar 10;281(10):927-30. doi: 10.1001/jama.281.10.927.
The risk of acquiring babesiosis by blood transfusion is largely unknown since in areas where it is endemic it is often an asymptomatic infection.
To investigate and treat a cluster of blood transfusion-associated babesiosis cases.
Case series and epidemiologic investigation.
Urban inner-city hospital.
Six persons who received Babesia microti-infected blood components from a donor.
Diagnosis and successful therapy of babesiosis following transfusion.
Six individuals (1 adult, 1 child, and 4 neonates) were exposed to products from a single blood donation by an asymptomatic Babesia-infected donor. Three of the 6 exposed patients became parasitemic. Polymerase chain reaction testing, animal inoculation studies, and indirect immunofluorescent antibody testing were used to confirm the presence of Babesia microti in the donor's blood and to establish the presence of infection in 3 of the 6 recipients. The 3 infected recipients and 1 additional recipient were treated without incident.
Physicians should consider babesiosis in the differential diagnosis of a febrile hemolytic disorder after blood transfusion. Prompt diagnosis is important since babesiosis is responsive to antibiotic therapy and, untreated, can be a fatal disease in certain risk groups.
由于在巴贝斯虫病流行地区，其感染通常无症状，因此通过输血感染巴贝斯虫病的风险很大程度上未知。
调查并治疗一组与输血相关的巴贝斯虫病病例。
病例系列研究和流行病学调查。
城市中心医院。
6名接受了来自一名供体的感染微小巴贝斯虫血液成分的人。
输血后巴贝斯虫病的诊断和成功治疗。
6人（1名成人、1名儿童和4名新生儿）接触了一名无症状感染巴贝斯虫的供体的单次献血产品。6名接触者中有3人出现寄生虫血症。采用聚合酶链反应检测、动物接种研究和间接免疫荧光抗体检测来确认供体血液中存在微小巴贝斯虫，并确定6名接受者中有3人感染。3名受感染的接受者和另外1名接受者接受了治疗，未出现意外情况。
医生在输血后发热性溶血性疾病的鉴别诊断中应考虑巴贝斯虫病。及时诊断很重要,因为巴贝斯虫病对抗生素治疗有反应，若不治疗，在某些风险人群中可能是致命疾病。
