Ohta S, Reutens D C, Gjedde A
McConnell Brain Imaging Center, Montreal Neurological Institute, and Department of Neurology and Neurosurgery, McGill University, Quebec, Canada.
J Cereb Blood Flow Metab. 1999 Mar;19(3):260-5. doi: 10.1097/00004647-199903000-00003.
Vibrotactile stimulation of the hand elicits no increase in oxygen consumption commensurate with the increase in blood flow measured in human sensory cortex. To test the hypothesis that previous failures to detect a proportionate increase in oxygen consumption could be an artefact of the sequential bolus, or three-step, method used to measure this parameter in the human brain in vivo, the authors compared the measurements with the results of a novel single bolus, or one-step, method of measuring oxygen consumption. The time of completion of the three-step method was 40 to 50 minutes, whereas the one-step method lasted only 3 minutes. The baseline whole-brain oxygen consumption averaged 185 +/- 32 micromol hg(-1) min(-1) by the three-step method and 153 +/- 15 micromol hg(-1) min(-1) by the one-step method. Vibrotactile stimulation did not elicit a significant increase in oxygen consumption measured by either method. This finding rejects the hypothesis that failure to detect an increase of oxygen consumption could be an artefact caused by limitations of the method used previously. Conversely, it also rejects the hypothesis that observations of an increase of oxygen consumption by the new method are artefacts caused by limitations of the one-step method.
对手部进行振动触觉刺激时，并未引发与人类感觉皮层中测量到的血流增加相称的氧消耗增加。为了检验此前未能检测到氧消耗成比例增加可能是用于在体测量人脑中该参数的顺序团注法（三步法）所导致的假象这一假设，作者将这些测量结果与一种新型的单次团注法（一步法）测量氧消耗的结果进行了比较。三步法完成的时间为40至50分钟，而一步法仅持续3分钟。通过三步法测得的全脑基础氧消耗平均为185±32微摩尔·汞柱⁻¹·分钟⁻¹，通过一步法测得的为153±15微摩尔·汞柱⁻¹·分钟⁻¹。振动触觉刺激并未使两种方法测得的氧消耗显著增加。这一发现否定了未能检测到氧消耗增加可能是由先前使用的方法的局限性所导致的假象这一假设。相反地，它也否定了通过新方法观察到的氧消耗增加是由一步法的局限性所导致的假象这一假设。
