Waterman F M, Kuchnir F T, Skaggs L S, Bewley D K, Page B C, Attix F H
Phys Med Biol. 1978 Jul;23(4):592-602. doi: 10.1088/0031-9155/23/4/002.
Incorporation of 10B in tumours treated by fast-neutron therapy would increase the tumour dose via the reaction 10B(n, alpha)7Li which occurs with partially thermalised neutrons. The extent of the dose enhancement was measured for neutron beams with median energies of 2.4, 3.3, 7.0 and 9.0 MeV by two techniques: with a BF3 proportional counter in three beams and activation of 23Na in the fourth. The results obtained with the two techniques are in good agreement. The magnitude of the dose enhancement depends upon the depth, field size and neutron beam energy. The dose enhancement at a depth of 8 cm varied from 0.32% with the lowest-energy beam to 0.07% with the highest-energy beam for each microgram of 10B uptake per gram of tissue. The products of the reaction in 10B would, however, have an RBE about twice that of the fast-neutron dose in the absence of boron. The method may be useful if drugs providing adequate uptake of 10B can be synthesised.
在快中子治疗的肿瘤中引入硼 - 10会通过硼 - 10与部分热化中子发生的10B(n,α)7Li反应增加肿瘤剂量。通过两种技术测量了能量中位数分别为2.4、3.3、7.0和9.0 MeV的中子束的剂量增强程度：在三束中子束中使用BF3正比计数器，在第四束中对钠 - 23进行活化。用这两种技术得到的结果吻合良好。剂量增强的幅度取决于深度、射野大小和中子束能量。对于每克组织摄取每微克硼 - 10，在8厘米深度处的剂量增强从最低能量束的0.32%到最高能量束的0.07%不等。然而，硼 - 10中反应的产物的相对生物效应约为无硼时快中子剂量的两倍。如果能够合成能使硼 - 10充分摄取的药物，该方法可能会有用。
