Rafałowska J
Department of Neurology, School of Medicine, Warszawa.
Folia Neuropathol. 1998;36(4):211-6.
The main factors in the pathogenesis of AIDS-dementia complex (ADC) are analyzed. The author suggests that these factors can be divided into two groups. The "nonspecific" factors present in every immunologic processes manifested by inflammation compose the first group. They are cytotoxic lymphocytes T, the immunoactivation of infected macrophages, cytokines, NO, NOS and iNOS, the increase of the BBB permeability, the accumulation of beta-amyloid precursor protein, excitotoxic amino acids, various and numerous cells adhesion molecules. The second group may contain factors connected with HIV-1 infection of CNS. In the pathogenesis of AIDS an important role is played by toxic glycoproteins gp 120 and gp 41 which are in the coat of HIV-1 virus, nucleotide sequences variability, possibility of various virus replication in various parts of CNS, the participation of lymphokines IL-4 and IL-10, and presence of co-receptors to HIV-1 virus on lymphocytes, macrophages, neurons and microglial cells.
分析了艾滋病痴呆综合征（ADC）发病机制中的主要因素。作者认为这些因素可分为两组。第一组是存在于由炎症表现出的每个免疫过程中的“非特异性”因素。它们是细胞毒性T淋巴细胞、被感染巨噬细胞的免疫激活、细胞因子、一氧化氮、一氧化氮合酶和诱导型一氧化氮合酶、血脑屏障通透性增加、β-淀粉样前体蛋白的积累、兴奋性毒性氨基酸、各种细胞黏附分子。第二组可能包含与中枢神经系统HIV-1感染相关的因素。在艾滋病发病机制中，HIV-1病毒包膜中的毒性糖蛋白gp 120和gp 41、核苷酸序列变异性、病毒在中枢神经系统各部位进行各种复制的可能性、淋巴因子IL-4和IL-10的参与以及淋巴细胞、巨噬细胞、神经元和小胶质细胞上HIV-1病毒共受体的存在都起着重要作用。
