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类鼻疽

Melioidosis.

作者信息

Beeker A, Van de Stadt K D, Bakker K

机构信息

Department of Internal Medicine, Spaarne Ziekenhuis Heemstede, The Netherlands.

出版信息

Neth J Med. 1999 Feb;54(2):76-9. doi: 10.1016/s0300-2977(98)00129-6.

DOI:10.1016/s0300-2977(98)00129-6
PMID:10079683
Abstract

Melioidosis is an infection with the gram-negative bacillus Burkholdria pseudomallei, previous known as Pseudomonas pseudomallei. We present a case report of a man with Non-Hodgkin's Lymphoma, who after visiting Indonesia presented himself with a urosepsis, with positive cultures to B. pseudomallei. Melioidosis is endemic in areas of southeast Asia and the northern part of Australia. Infection with the B. pseudomallei has a high mortality rate. Diagnosis can be made on the basis of cultures, the bacteria grow on standard media. Treatment should be based up on sensitivity studies. The optimum duration of therapy and choice of antibiotics remain to be determined. Due to the increase in travel, the infection will be seen more frequently in other parts of the world.

摘要

类鼻疽是由革兰氏阴性杆菌伯克霍尔德菌(以前称为类鼻疽假单胞菌)引起的感染。我们报告一例非霍奇金淋巴瘤患者,该患者在访问印度尼西亚后出现泌尿道脓毒症,类鼻疽伯克霍尔德菌培养呈阳性。类鼻疽在东南亚和澳大利亚北部地区为地方病。感染类鼻疽伯克霍尔德菌死亡率很高。诊断可基于培养结果,该细菌可在标准培养基上生长。治疗应基于敏感性研究。最佳治疗持续时间和抗生素选择仍有待确定。由于旅行增加,这种感染在世界其他地区将更频繁地出现。

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引用本文的文献

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The Evolving Global Epidemiology of Human Melioidosis: A Narrative Review.人类类鼻疽病不断演变的全球流行病学:叙述性综述
Pathogens. 2024 Oct 24;13(11):926. doi: 10.3390/pathogens13110926.
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Melioidosis: Clinical impact and public health threat in the tropics.类鼻疽:热带地区的临床影响与公共卫生威胁
PLoS Negl Trop Dis. 2017 May 11;11(5):e0004738. doi: 10.1371/journal.pntd.0004738. eCollection 2017 May.
3
Emergence of Melioidosis in Indonesia.印度尼西亚出现类鼻疽病。
Am J Trop Med Hyg. 2015 Dec;93(6):1160-1163. doi: 10.4269/ajtmh.15-0292. Epub 2015 Oct 12.
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Cloning, purification, crystallization and preliminary X-ray analysis of the Burkholderia pseudomallei L1 ribosomal protein.类鼻疽伯克霍尔德菌L1核糖体蛋白的克隆、纯化、结晶及初步X射线分析
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Mar 1;68(Pt 3):347-50. doi: 10.1107/S1744309112004800. Epub 2012 Feb 22.
5
Melioidosis: epidemiology, pathophysiology, and management.类鼻疽病:流行病学、病理生理学及管理
Clin Microbiol Rev. 2005 Apr;18(2):383-416. doi: 10.1128/CMR.18.2.383-416.2005.
6
A mutant of Burkholderia pseudomallei, auxotrophic in the branched chain amino acid biosynthetic pathway, is attenuated and protective in a murine model of melioidosis.一种在支链氨基酸生物合成途径中营养缺陷型的类鼻疽伯克霍尔德菌突变体,在类鼻疽病的小鼠模型中减毒且具有保护性。
Infect Immun. 2002 Sep;70(9):5290-4. doi: 10.1128/IAI.70.9.5290-5294.2002.