Danilkina E B, Smolikova L M, Mironova A V, Sanamiants E M
Research Plague Institute, Rostov-on-Don.
Antibiot Khimioter. 1998;43(11):6-10.
The recent increase of the number of antimicrobials and isolation of antibiotic resistant strains from humans and environmental objects is indicative of the necessity of further investigation of antibiotic susceptibility of the representatives of the genus Vibrio pathogenic for man to provide rational therapy of the diseases due to them. Susceptibility of 160 strains of pathogenic vibrios of 9 species to 11 antibiotics and chemotherapeutic drugs was assayed by the method of serial dilutions in agar media. The isolates were shown to be highly susceptible to chloramphenicol, doxycycline, cefotaxime, nalidixic acid and ciprofloxacin which made it possible to consider them as the drugs of choice in the treatment of the diseases caused by the microorganisms. A tendency to form polyantibiotic resistant strains within every species of tested pathogenic vibrios was observed. It conditioned the prospects of further profound study of the phenomenon with the analysis of the genetic determination of antibiotic resistance markers in pathogenic vibrios.
近期，人类和环境物体中抗菌药物数量的增加以及抗生素耐药菌株的分离表明，有必要进一步研究对人类致病的弧菌属细菌的抗生素敏感性，以便为因这些细菌引起的疾病提供合理的治疗方案。采用琼脂培养基连续稀释法，检测了9种160株致病性弧菌对11种抗生素和化疗药物的敏感性。结果显示，这些分离株对氯霉素、强力霉素、头孢噻肟、萘啶酸和环丙沙星高度敏感，这使得它们有可能被视为治疗由这些微生物引起疾病的首选药物。在所检测的每种致病性弧菌中，均观察到形成多重耐药菌株的趋势。这为进一步深入研究该现象以及分析致病性弧菌抗生素耐药标记的遗传决定因素奠定了基础。
