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AZT-5'-(p-bromophenyl methoxyalaninyl phosphate) as a potent and non-toxic anti-human immunodeficiency virus agent.

作者信息

Jan S T, Zhu Z, Tai H L, Shih M J, Venkatachalam T K, Uckun F M

机构信息

Drug Discovery Program, Hughes Institute, Roseville, MN 55113, USA.

出版信息

Antivir Chem Chemother. 1999 Jan;10(1):47-52. doi: 10.1177/095632029901000106.

DOI:10.1177/095632029901000106
PMID:10079879
Abstract

The potency and selectivity index of the AZT-phenyl phosphate derivatives in thymidine kinase (TK)-deficient T cells were substantially enhanced by introducing a single para-bromo substitutent in the phenyl moiety. AZT-5'-(p-bromophenyl methoxyalaninyl phosphate) was 43-fold more potent than AZT-5'-(phenyl methoxyalaninyl phosphate) and was fivefold more potent than AZT in inhibiting human immunodeficiency virus (HIV) replication in TK-deficient CEM cells.

摘要

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