用于帕金森病的神经移植
Neural transplantation for Parkinson's disease.
作者信息
Date I, Ohmoto T
机构信息
Department of Neurological Surgery, Okayama University Medical School, Japan.
出版信息
Cell Mol Neurobiol. 1999 Feb;19(1):67-78. doi: 10.1023/a:1006964507916.
Abstract
- Neural transplantation is one promising approach for the treatment of Parkinson's disease. Fetal substantia nigra cells are a good source of dopamine, but in order to avoid ethical and immunological problems, adrenal medullary chromaffin cells have been investigated as an alternative source. 2. Grafted adrenal medullary chromaffin cells can provide dopamine as well as several neurotrophic factors that affect dopaminergic neurons in the brain. 3. We review experimental studies for application of neural transplantation techniques in Parkinson's disease, including immunological studies, cryopreservation, microvasculature, donor tissue, and direct gene delivery studies performed in our laboratory. Our clinical experience and new approach involving a polymer-encapsulated cell grafting procedure are also described.
摘要
- 神经移植是治疗帕金森病的一种有前景的方法。胎儿黑质细胞是多巴胺的良好来源，但为了避免伦理和免疫问题，肾上腺髓质嗜铬细胞已被作为替代来源进行研究。2. 移植的肾上腺髓质嗜铬细胞可以提供多巴胺以及几种影响脑中多巴胺能神经元的神经营养因子。3. 我们回顾了神经移植技术在帕金森病中应用的实验研究，包括我们实验室进行的免疫学研究、冷冻保存、微血管系统、供体组织和直接基因递送研究。还描述了我们的临床经验以及涉及聚合物包裹细胞移植程序的新方法。
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