Sezer A D, Akbuğa J
University of Marmara, Faculty of Pharmacy, Haydarpaşa-Istanbul, Turkey.
J Microencapsul. 1999 Mar-Apr;16(2):195-203. doi: 10.1080/026520499289176.
Alginate and chitosan treated alginate beads were prepared and compared as an oral controlled release system for macromolecular drugs. Dextran (M.W. 70,000) was used as a model substance. The beads were prepared by the ionotropic gelation method and the effect of various factors (alginate, chitosan, drug and calcium chloride concentrations, the volume of external and internal phases and drying methods) on bead properties were investigated. The addition of chitosan increased the drug loading capacity of the beads, and larger beads were obtained in the presence of chitosan. On the other hand, addition of chitosan in the gel structure reduced the drug release from beads. The erosion of the beads was suppressed by chitosan treatment. The drying method was important to the properties of the chitosan-alginate beads. It is proposed that chitosan treated alginate beads may be used as a potential controlled release system of such macromolecules.
制备了海藻酸盐和壳聚糖处理的海藻酸盐珠，并将其作为大分子药物的口服控释系统进行比较。使用葡聚糖（分子量70,000）作为模型物质。通过离子凝胶法制备珠子，并研究了各种因素（海藻酸盐、壳聚糖、药物和氯化钙浓度、外相和内相体积以及干燥方法）对珠子性质的影响。壳聚糖的添加增加了珠子的载药量，并且在壳聚糖存在的情况下获得了更大的珠子。另一方面，在凝胶结构中添加壳聚糖减少了药物从珠子中的释放。壳聚糖处理抑制了珠子的侵蚀。干燥方法对壳聚糖-海藻酸盐珠的性质很重要。有人提出，壳聚糖处理的海藻酸盐珠可作为此类大分子的潜在控释系统。
