Casas M, Prat G, Robledo P, Jané F
Institut de Recerca Sant Pau, Hospital de la Santa Creu i Sant Pau, Departament de Psiquiatria, Universitat Autònoma de Barcelona, Spain.
Pharmacol Biochem Behav. 1999 Mar;62(3):481-5. doi: 10.1016/s0091-3057(98)00216-0.
Previous studies using the turning behavior animal model have shown both increases and decreases in rotational behavior following successive administrations of dopamine agonists. To clarify the results obtained with this model, we studied the variability of rotational behavior after repeated challenges with low doses of apomorphine (0.05 mg/kg) at different time intervals ranging between 2 h and 14 days. Results show a decrease in the total number of turns with time intervals of 2, 6, and 12 h between administrations, and an increase in the total number of turns when apomorphine was administered once every 24 h. In contrast, when animals were tested at 7- and 14-day intervals, a stable number of turns in successive challenges was obtained. These results suggest that when successive injections of dopamine agonists are administered at sufficiently long intervals of time, the neuroadaptations that take place due to repeated drug exposure may not be apparent. These findings are relevant for the design of future experiments using this model.
以往使用旋转行为动物模型的研究表明，在连续给予多巴胺激动剂后，旋转行为既有增加也有减少。为了阐明用该模型获得的结果，我们研究了在2小时至14天的不同时间间隔用低剂量阿扑吗啡（0.05mg/kg）重复激发后旋转行为的变异性。结果显示，给药间隔为2小时、6小时和12小时时，总旋转次数随时间间隔减少，而每24小时给药一次阿扑吗啡时，总旋转次数增加。相比之下，当以7天和14天的间隔对动物进行测试时，在连续激发中获得了稳定的旋转次数。这些结果表明，当以足够长的时间间隔连续注射多巴胺激动剂时，由于反复接触药物而发生的神经适应性变化可能不明显。这些发现与使用该模型的未来实验设计相关。
