Thulborn K R, Davis D, Adams H, Gindin T, Zhou J
MR Research Center, Department of Radiology, University of Pittsburgh, Pennsylvania, USA.
Magn Reson Med. 1999 Feb;41(2):351-9. doi: 10.1002/(sici)1522-2594(199902)41:2<351::aid-mrm20>3.0.co;2-h.
Tissue sodium concentration (TSC), as determined by in vivo 23Na magnetic resonance imaging (MRI) and the ex vivo classical 22Na radionuclide dilution assay (RDA), has been compared in a rat model of a focal glioma. The 23Na MRI method used a three-dimensional, twisted projection acquisition scheme at short echo time to minimize signal losses from relaxation of transverse magnetization. Calibration standards within the field of view allowed quantification of the sodium signal in terms of a TSC after correction for B1 nonuniformity and tissue water concentration. The 23Na MRI method measured focally increased TSC values in tumors that were equivalent statistically to the destructive 22Na RDA method. The noninvasive 23Na MRI method provided a quantitative means with which to monitor focal brain tumor growth.
通过体内23Na磁共振成像（MRI）和体外经典22Na放射性核素稀释测定法（RDA）测定的组织钠浓度（TSC），已在局灶性胶质瘤大鼠模型中进行了比较。23Na MRI方法在短回波时间使用三维扭曲投影采集方案，以尽量减少横向磁化弛豫造成的信号损失。视野内的校准标准允许在校正B1不均匀性和组织水浓度后，根据TSC对钠信号进行定量。23Na MRI方法测量的肿瘤中局灶性升高的TSC值在统计学上与破坏性的22Na RDA方法相当。无创的23Na MRI方法提供了一种监测局灶性脑肿瘤生长的定量手段。
